Their findings pointed to the latter-but researchers still haven’t ruled out the possibility that the virus has direct effects on the brain. Going into that study, Jehi says, her team wanted to determine whether the SARS-CoV-2 virus was entering the brain and causing damage directly, or triggering an immune response that led to brain changes. “We found many areas of overlap between the two, and these areas of overlap centered on…inflammation in the brain and microscopic injuries to the blood vessels,” she says. And in a 2021 study, Jehi and her colleagues compared the brains of people with Long COVID and Alzheimer’s disease. She’s found evidence of abnormal inflammation in people with chronic post-COVID headaches.
Lara Jehi, who researches COVID-19 and the brain at the Cleveland Clinic, also points to inflammation as a possible trigger for COVID-19’s neurologic symptoms. In people who survive COVID-19, brain inflammation may also explain years-long symptoms like brain fog and memory loss-though “we don’t know for sure,” Nath says.ĭr.
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